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In contrast, increased frontal activation and/or normalization of abnormal connectivity have been associated with improvement of pain and of sad mood (Ong et al., 2019)

Methylene blue is not an FDA approved cure for cancer, it is an experimental treatment being researched that may not be effective in all cases

Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow

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The regulatory status varies by country and jurisdiction

Int J Mol Sci 24(4):3207 [DOI] [PMC free article] [PubMed] [Google Scholar] Wang Y, Wu L, Fu J, Lv H, Guan X, Xu L, Chen P, Gao C, Hou P, Ji M (2013) Hyperthyroid monkeys: a nonhuman primate model of experimental Graves disease